Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand-Reference-Cited by-同舟云学术

Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

Published:2020-07-14 Issue:15 Volume:63 Page:8608-8633
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Longbin¹^ORCID,Prime Michael E.²,Lee Matt R.¹,Khetarpal Vinod¹,Brown Christopher J.²,Johnson Peter D.²,Miranda-Azpiazu Patricia³,Chen Xuemei⁴,Clark-Frew Daniel²,Coe Samuel²,Davis Randall⁴,Dickie Anthony²,Ebneth Andreas²,Esposito Simone⁵,Gadouleau Elise²,Gai Xinjie²,Galan Sebastien²,Green Samantha²,Greenaway Catherine²,Giles Paul²,Halldin Christer³,Hayes Sarah²,Herbst Todd¹,Herrmann Frank⁶,Heßmann Manuela⁶,Jia Zhisheng³,Kiselyov Alexander¹,Kotey Adrian²,Krulle Thomas²,Mangette John E.⁴,Marston Richard W.²,Menta Sergio⁵,Mills Matthew R.²,Monteagudo Edith⁵,Nag Sangram³^ORCID,Nibbio Martina⁵,Orsatti Laura⁵,Schaertl Sabine⁶,Scheich Christoph⁶,Sproston Joanne²,Stepanov Vladimir³,Svedberg Marie³,Takano Akihiro³,Taylor Malcolm²,Thomas Wayne²,Toth Miklós³,Vaidya Darshan²,Vanräs Katarina³,Weddell Derek²,Wigginton Ian²,Wityak John¹,Mrzljak Ladislav¹,Munoz-Sanjuan Ignacio¹,Bard Jonathan A.¹^ORCID,Dominguez Celia¹

Affiliation:

1. CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States

2. Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.

3. Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden

4. Albany Molecular Research, Inc., 1001 Main St., Buffalo, New York 14203, United States

5. IRBM, IRBM Science Park S.p.A., Via Pontina Km 30, 600, 00071 Pomezia (RM), Italy

6. Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany

Funder

CHDI Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00955

Reference63 articles.

1. Huntington disease

2. The hunt for huntingtin function: interaction partners tell many different stories

3. The selective vulnerability of nerve cells in Huntington's disease

4. Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?

5. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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