Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists-Reference-Cited by-同舟云学术

Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists

Published:2023-04-03 Issue:7 Volume:66 Page:4588-4602
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lautala Saara¹^ORCID,Provenzani Riccardo²^ORCID,Tarvainen Ilari³^ORCID,Sirna Katia²^ORCID,Karhu S. Tuuli³^ORCID,Grazhdankin Evgeni²^ORCID,Lehtinen Antti K.²^ORCID,Sa’d Hanan¹⁴,Koivuniemi Artturi¹,Xhaard Henri²^ORCID,Tuominen Raimo K.³^ORCID,Talman Virpi³^ORCID,Bunker Alex¹^ORCID,Yli-Kauhaluoma Jari²^ORCID

Affiliation:

1. Drug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland

2. Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland

3. Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland

4. School of Pharmacy, The University of Jordan, Queen Rania Street, 11942 Amman, Jordan

Funder

Finnish Center for Artificial Intelligence

Academy of Finland

University of Helsinki

Finnish Foundation for Cardiovascular Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01448