Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer-Reference-Cited by-同舟云学术

Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer

Published:2022-10-07 Issue:21 Volume:65 Page:14337-14347
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mudd Gemma E.¹^ORCID,Scott Heather¹,Chen Liuhong¹,van Rietschoten Katerine¹,Ivanova-Berndt Gabriela¹,Dzionek Katarzyna¹,Brown Amy¹^ORCID,Watcham Sophie¹,White Lewi¹,Park Peter U.²,Jeffrey Phil¹,Rigby Mike¹,Beswick Paul¹

Affiliation:

1. BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.

2. Bicycle Therapeutics, Inc., 4 Hartwell Place, Lexington 02421-3122, Massachusetts, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00065

Reference26 articles.

1. Pharmacokinetic (PK) assessment of BT1718: A phase I/II a study of BT1718, a first in class bicycle toxin conjugate (BTC), in patients (pts) with advanced solid tumours

2. Abstract 1167: Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of lung cancer

3. Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads

4. Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors

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