Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads-Reference-Cited by-同舟云学术

Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads

Published:2020-03-23 Issue:8 Volume:63 Page:4107-4116
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mudd Gemma E.¹^ORCID,Brown Amy¹,Chen Liuhong¹,van Rietschoten Katerine¹,Watcham Sophie¹,Teufel Daniel P.¹,Pavan Silvia¹,Lani Rachid¹,Huxley Philip¹,Bennett Gavin S.¹

Affiliation:

1. BicycleTx Limited, Building 900, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b02129

Reference34 articles.

1. Phage-encoded combinatorial chemical libraries based on bicyclic peptides

2. Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologues While Sparing Paralogous Proteases

3. A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

4. Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors

5. A Cancer Research UK phase I/IIa trial of BT1718 (a first in class Bicycle Drug Conjugate) given intravenously in patients with advanced solid tumours.

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