Structure-Based Discovery and Optimization of Furo[3,2-<i>c</i>]pyridin-4(5<i>H</i>)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors-Reference-Cited by-同舟云学术

Structure-Based Discovery and Optimization of Furo[3,2-c]pyridin-4(5H)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors

Published:2022-03-25 Issue:7 Volume:65 Page:5760-5799
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Junhua¹²,Zhang Cheng¹,Xu Hongrui¹³,Wang Chao¹²,Dong Ruibo¹⁴,Shen Hui¹²,Zhuang Xiaoxi¹,Chen Xiaoshan¹²,Li Qiu¹²,Lu Jibu¹²,Zhang Maofeng⁵,Wu Xishan¹,Loomes Kerry M.⁶^ORCID,Zhou Yulai⁴,Zhang Yan¹,Liu Jinsong¹⁷^ORCID,Xu Yong¹³⁸⁷

Affiliation:

1. Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China

2. University of Chinese Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, China

3. Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Guangzhou Medical University, Chinese Academy of Sciences, Guangzhou 510530, China

4. School of Pharmaceutical Sciences, Jilin University, No. 1266 Fujin Road, Chaoyang District, Changchun, Jilin 130021, China

5. College of Pharmacy, Taizhou Polytechnic College, Taizhou 225300, China

6. School of Biological Sciences & Maurice Wilkins Centre, University of Auckland, Auckland 1010, New Zealand

7. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

8. China−New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou 510530, China

Funder

Ministry of Science and Technology of the People's Republic of China

State Key Laboratory of Respiratory Disease

Guangzhou Science and Technology Program key projects

National Natural Science Foundation of China

Chinese Academy of Sciences

Guangdong Basic and Applied Basic Research Foundation