Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia-Reference-Cited by-同舟云学术

Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia

Published:2024-01-04 Issue:2 Volume:67 Page:1513-1532
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jiang Wenhua¹²,Hou Qiangqiang¹²,Xu Hongrui³,Yang Kexin¹²,Wang Xiaohui¹²,Zhang Kuojun¹²^ORCID,Zeng Yi¹²,Li Wenqiang¹²,Wang Bingrui¹²,Luo Guangmei¹²,Zhao Xiaofan⁴,Shen Hui³,Xu Yong³⁵⁶^ORCID,Wu Xiaoxing¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China

2. Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China

3. Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China

4. GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, 511436, China

5. China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou, 510530, China

6. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02104

Reference62 articles.

1. Targeting bromodomains: epigenetic readers of lysine acetylation

2. Structure and ligand of a histone acetyltransferase bromodomain

3. Bromodomains: a new target class for drug development

4. BET domain co-regulators in obesity, inflammation and cancer

5. BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection

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