Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors-Reference-Cited by-同舟云学术

Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors

Published:2022-07-26 Issue:15 Volume:65 Page:10408-10418
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Shengrong¹,Zhang Pengwei²³^ORCID,Xu Fang¹,Hu Shengcao¹,Liu Jiacong¹,Tan Yi¹,Tu Zhengchao¹,Sun Hongyan⁴^ORCID,Zhang Zhi-Min¹,He Qing-Yu²⁵^ORCID,Sun Pinghua¹,Ding Ke¹^ORCID,Li Zhengqiu¹⁵^ORCID

Affiliation:

1. School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China 510632

2. Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China

3. Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong, China

4. Department of Chemistry, City University of Hong Kong, Hong Kong 999077, China

5. MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou 510120, China

Funder

National Natural Science Foundation of China

Science and Technology Program of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00272

Reference49 articles.

1. Targeted Covalent Inhibitors for Drug Design

2. Structure-based design of targeted covalent inhibitors

3. Covalent inhibitors: an opportunity for rational target selectivity

4. Drug discovery considerations in the development of covalent inhibitors

5. The Cysteinome of Protein Kinases as a Target in Drug Development

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