Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr<sup>705</sup>/Ser<sup>727</sup> Inhibitory Activity for Gastric Cancer Treatment-Reference-Cited by-同舟云学术

Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr⁷⁰⁵/Ser⁷²⁷ Inhibitory Activity for Gastric Cancer Treatment

Published:2022-09-14 Issue:19 Volume:65 Page:12650-12674
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

He Peng¹^ORCID,Miao Ying¹,Sun Yue¹,Bian Aiwu¹,Jin Wangrui¹,Chen Huang¹,Ye Jiangnan¹,He Jia¹,Peng Yangrui¹,Gu Haijun¹^ORCID,Liu Mingyao¹^ORCID,Yi Zhengfang¹^ORCID,Chen Yihua¹^ORCID

Affiliation:

1. Shanghai Key Laboratory of Regulatory Biology, The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China

Funder

East China Normal University

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00413

Reference50 articles.

1. Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies