Studying Lipophilicity Trends of Phosphorus Compounds by <sup>31</sup>P-NMR Spectroscopy: A Powerful Tool for the Design of P-Containing Drugs-Reference-Cited by-同舟云学术

Studying Lipophilicity Trends of Phosphorus Compounds by ³¹P-NMR Spectroscopy: A Powerful Tool for the Design of P-Containing Drugs

Published:2022-06-09 Issue:12 Volume:65 Page:8511-8524
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Columbus Ishay¹^ORCID,Ghindes-Azaria Lee¹,Chen Ravit¹^ORCID,Yehezkel Lea¹,Redy-Keisar Orit¹^ORCID,Fridkin Gil¹^ORCID,Amir Dafna¹,Marciano Daniele¹^ORCID,Drug Eyal²,Gershonov Eytan¹,Klausner Ziv³^ORCID,Saphier Sigal¹^ORCID,Elias Shlomi¹,Pevzner Alexander⁴,Eichen Yoav⁵^ORCID,Parvari Galit⁵,Smolkin Boris¹^ORCID,Zafrani Yossi¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, Israel

2. Department of Analytical Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, Israel

3. Department of Applied Mathematics, Israel Institute for Biological Research, Ness-Ziona 74100, Israel

4. Department of Physical Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, Israel

5. Schulich Faculty of Chemistry Technion, Israel Institute of Technology, Technion City, Haifa 3200008, Israel

Funder

Israeli Prime Minister's office

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00658

Reference56 articles.

1. The influence of drug-like concepts on decision-making in medicinal chemistry

2. Lipophilic Efficiency as an Important Metric in Drug Design

3. Molecular obesity, potency and other addictions in drug discovery

4. An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs

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