Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor
Author:
Affiliation:
1. Research Division, Chugai Pharmaceutical Co. Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan
2. Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan
Funder
Chugai Pharmaceutical
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01099
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2. Early Process Development of CH7057288, a Benzofuran-Containing Selective NTRK Inhibitor;Organic Process Research & Development;2024-01-03
3. Recent advances in the discovery of tropomyosin receptor kinases TRKs inhibitors: A mini review;European Journal of Medicinal Chemistry;2023-10
4. Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations;Journal of Medicinal Chemistry;2023-09-07
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