Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations-Reference-Cited by-同舟云学术

Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations

Published:2023-09-07 Issue:18 Volume:66 Page:12950-12965
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Zuqin¹,Wang Jie¹,Wang Yongjin¹,Xiang Shuang¹,Zhou Hengliang¹,Song Shukai¹,Song Xiaojuan¹,Tu Zhengchao¹,Zhou Yang¹^ORCID,Ding Ke¹^ORCID,Zhang Zhi-Min¹,Zhang Zhang¹^ORCID,Lu Xiaoyun¹^ORCID

Affiliation:

1. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China

Funder

Guangdong Science and Technology Department

State Key Laboratory of Respiratory Disease

Basic and Applied Basic Research Foundation of Guangdong Province

Jinan University

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00899