Is Target-Based Drug Discovery Efficient? Discovery and “Off-Target” Mechanisms of All Drugs-Reference-Cited by-同舟云学术

Is Target-Based Drug Discovery Efficient? Discovery and “Off-Target” Mechanisms of All Drugs

Published:2023-09-06 Issue:18 Volume:66 Page:12651-12677
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sadri Arash¹²³^ORCID

Affiliation:

1. Lyceum Scientific Charity, Tehran, Iran, 1415893697

2. Interdisciplinary Neuroscience Research Program (INRP), Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran, 1417755331

3. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran, 1417614411

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01737

Reference442 articles.

1. The productivity crisis in pharmaceutical R&D

2. Analysis of pharma R&D productivity – a new perspective needed

3. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

4. Estimation of clinical trial success rates and related parameters

5. Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018

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