Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects-Reference-Cited by-同舟云学术

Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects

Published:2022-06-06 Issue:12 Volume:65 Page:8444-8455
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Meng-Xing¹,Tian Yi-Jing¹,Han Chuan¹,Liu Run-Duo¹,Xie Xi²,Yuan Yijun²,Yang Yi-Yi¹,Li Zhe¹,Chen Jianwen¹,Luo Hai-Bin¹²³^ORCID,Wu Yinuo¹

Affiliation:

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

2. Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute, School of Life and Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China

3. Song Li’ Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya 572000, China

Funder

Natural Science Foundation of Guangzhou City

Hainan University

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00458

Reference26 articles.

1. Phosphodiesterases in the CNS: targets for drug development

2. Role of phosphodiesterase 1 in the pathophysiology of diseases and potential therapeutic opportunities

3. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

4. Advances in targeting cyclic nucleotide phosphodiesterases

5. PDE1 inhibitors: a review of the recent patent literature (2008-present)

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