Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions
Author:
Affiliation:
1. Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00442
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5. Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa
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2. The molecular structure of 4-substituted pyridine N-oxides–boron trifluoride triel bonded complexes: Peculiarities and regularities;Computational and Theoretical Chemistry;2023-12
3. Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives;Journal of Medicinal Chemistry;2023-04-10
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