Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT-Reference-Cited by-同舟云学术

Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT

Published:2022-11-28 Issue:23 Volume:65 Page:15725-15737
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cheng Junfei¹,He Shipeng²,Xu Jun³,Huang Min³,Dong Guoqiang¹^ORCID,Sheng Chunquan¹^ORCID

Affiliation:

1. School of Pharmacy, Second Military Medical University (Navy Medical University), Shanghai 200433, China

2. Institute of Translational Medicine, Shanghai University, Shanghai 200444, China

3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Shanghai Rising-Star Program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01243

Reference26 articles.

1. Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

2. Small-Molecule PROTACS: New Approaches to Protein Degradation

3. Induced protein degradation: an emerging drug discovery paradigm

4. Targeted protein degradation by PROTACs

5. Small-molecule PROTACs: novel agents for cancer therapy

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