Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1-Reference-Cited by-同舟云学术

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Published:2022-06-08 Issue:13 Volume:65 Page:9011-9033
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pöhner Ina¹²^ORCID,Quotadamo Antonio³⁴,Panecka-Hofman Joanna¹⁵^ORCID,Luciani Rosaria⁶,Santucci Matteo⁶,Linciano Pasquale⁶,Landi Giacomo⁷,Di Pisa Flavio⁷,Dello Iacono Lucia⁷,Pozzi Cecilia⁷^ORCID,Mangani Stefano⁷^ORCID,Gul Sheraz⁸,Witt Gesa⁸,Ellinger Bernhard⁸,Kuzikov Maria⁸^ORCID,Santarem Nuno⁹,Cordeiro-da-Silva Anabela⁹¹⁰,Costi Maria P.⁶^ORCID,Venturelli Alberto³⁶,Wade Rebecca C.¹²¹¹¹²^ORCID

Affiliation:

1. Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (HITS), D-69118 Heidelberg, Germany

2. Faculty of Biosciences, Heidelberg University, D-69120 Heidelberg, Germany

3. Tydock Pharma srl, Strada Gherbella 294/B, 41126 Modena, Italy

4. Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, 41121 Modena, Italy

5. Faculty of Physics, University of Warsaw, 02-093 Warsaw, Poland

6. Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy

7. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy

8. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany

9. Instituto de Investigação e Inovação em Saúde, Institute for Molecular and Cell Biology, Universidade do Porto, 4200-135 Porto, Portugal

10. Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal

11. Center for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, D-69120 Heidelberg, Germany

12. Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, D-69120 Heidelberg, Germany

Funder

European Commission

Narodowe Centrum Nauki

Klaus Tschira Stiftung

Center for Modelling and Simulation in the Biosciences

Interdisciplinary Centre for Mathematical and Computational Modelling (ICM), University of Warsaw

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00232

Reference85 articles.

1. Neglected tropical diseases. https://www.who.int/neglected_diseases/en/ (accessed May 2020).

2. The WHO Strategic and Technical Advisory Group for Neglected Tropical Diseases (WHO STAG). https://www.who.int/publications/i/item/9789240015098.

3. The trypanosomiases

4. Clinical aspects of 2541 patients with second stage human African trypanosomiasis

5. Kinetoplastids: related protozoan pathogens, different diseases

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