Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes-Reference-Cited by-同舟云学术

Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes

Published:2022-10-26 Issue:21 Volume:65 Page:14539-14552
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dammann Marcel¹,Stahlecker Jason¹,Zimmermann Markus O.¹,Klett Theresa¹^ORCID,Rotzinger Kilian¹,Kramer Markus²,Coles Murray³^ORCID,Stehle Thilo⁴,Boeckler Frank M.¹⁵^ORCID

Affiliation:

1. Laboratory for Molecular Design & Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076Tübingen, Germany

2. Institute of Organic Chemistry, Eberhard Karls Universität Tübingen, 72076Tübingen, Germany

3. Department of Protein Evolution, Max-Planck-Institute for Developmental Biology, 72076Tübingen, Germany

4. Interfaculty Institute of Biochemistry, Eberhard Karls Universität Tübingen, 72076Tübingen, Germany

5. Interfaculty Institute for Biomedical Informatics (IBMI), Eberhard Karls Universität Tübingen, 72076Tübingen, Germany

Funder

Deutsche Forschungsgemeinschaft

Eberhard Karls Universit?t T?bingen

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00951

Reference68 articles.

1. Fragment-to-Lead Medicinal Chemistry Publications in 2020

2. A bright future for fragment-based drug discovery: what does it hold?

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5. Embracing the Diversity of Halogen Bonding Motifs in Fragment-Based Drug Discovery—Construction of a Diversity-Optimized Halogen-Enriched Fragment Library

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