Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4-Reference-Cited by-同舟云学术

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4

Published:2022-06-22 Issue:13 Volume:65 Page:8843-8854
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Priestley E. Scott¹^ORCID,Banville Jacques²,Deon Daniel²,Dubé Laurence²,Gagnon Marc²,Guy Julia²,Lapointe Philippe²,Lavallée Jean-François²,Martel Alain²,Plamondon Serge²,Rémillard Roger²,Ruediger Edward²,Tremblay François²,Posy Shana L.¹,Guarino Victor R.¹,Richter Jeremy M.¹^ORCID,Li Jianqing¹^ORCID,Gupta Anuradha³^ORCID,Vetrichelvan Muthalagu³^ORCID,Balapragalathan T. J.³,Mathur Arvind¹,Hua Ji¹,Callejo Mario²,Guay Jocelyne²,Sum Chi Shing¹,Cvijic Mary Ellen¹,Watson Carol¹,Wong Pancras¹,Yang Jing¹,Bouvier Michel²⁴^ORCID,Gordon David A.¹,Wexler Ruth R.¹,Marinier Anne²⁵

Affiliation:

1. Bristol-Myers Squibb Research & Early Development, 3551 Lawrenceville Road, Princeton, New Jersey08540, United States

2. Institute for Research in Immunology and Cancer, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QuébecH3C 3J7, Canada

3. Department of Discovery Synthesis, Biocon Bristol-Myers Squibb R&D Centre, Syngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra−Jigani Road, Bangalore560099, India

4. Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QuébecH3C 3J7, Canada

5. Department of Chemistry and Department of Pharmacology, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QuébecH3C 3J7, Canada

Funder

Ministère de l'Économie, de la Science et de l'Innovation - Québec

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00359

Reference30 articles.

1. Heart Disease and Stroke Statistics—2021 Update