Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide
Author:
Affiliation:
1. Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States
Funder
Academic Health Center, University of Minnesota
National Institute of General Medical Sciences
National Cancer Institute
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00274
Reference54 articles.
1. Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
2. DNA topoisomerase II and its growing repertoire of biological functions
3. Drugging Topoisomerases: Lessons and Challenges
4. DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
5. TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo
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2. Synthesis of Myrtucommulone D: A Selective Inhibitor of Tyrosyl-DNA Phosphodiesterase 2 Promoting Drug Resistance Reversal in Lung Cancer Cells;Revista Brasileira de Farmacognosia;2024-01-05
3. Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents;Genes;2023-10-12
4. Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding;Journal of Biological Chemistry;2023-08
5. Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities;European Journal of Medicinal Chemistry;2022-08
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