Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay-Reference-Cited by-同舟云学术

Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay

Published:2019-08-17 Issue:17 Volume:62 Page:7885-7896
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ayotte Yann¹^ORCID,Marando Victoria M.²^ORCID,Vaillancourt Louis²,Bouchard Patricia²,Heffron Gregory³,Coote Paul W.²³,Larda Sacha T.²,LaPlante Steven R.¹²³^ORCID

Affiliation:

1. INRS-Centre Armand-Frappier Santé Biotechnologie, 531 Boulevard des Prairies, Laval, Québec H7V 1B7, Canada

2. NMX Research and Solutions, Inc., 500 Boulevard Cartier Ouest, Laval, Québec, H7V 5B7, Canada

3. Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, United States

Funder

Natural Sciences and Engineering Research Council of Canada

Mitacs

Quebec Network for Research on Protein Function, Structure, and Engineering (PROTEO)

NMX Research and Solutions Inc.

Quebec Consortium for Drug Discovery

Canadian Foundation for Innovation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00653

Reference75 articles.

1. Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability

2. Building nanostructures with drugs

3. Identification of small molecule aggregators from large compound libraries by support vector machines

4. Compound Aggregation in Drug Discovery: Implementing a Practical NMR Assay for Medicinal Chemists

5. Monitoring Drug Self-Aggregation and Potential for Promiscuity in Off-Target In Vitro Pharmacology Screens by a Practical NMR Strategy

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