Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization-Reference-Cited by-同舟云学术

Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization

Published:2020-07-07 Issue:21 Volume:63 Page:12156-12170
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Miller Randy R.¹^ORCID,Madeira Maria¹,Wood Harold B.²,Geissler Wayne M.³,Raab Conrad E.⁴,Martin Iain J.⁵

Affiliation:

1. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States

2. Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

3. Business Development & Licensing, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

4. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States

5. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01813

Reference67 articles.

1. Probing the links between in vitro potency, ADMET and physicochemical parameters

2. Lipophilic Efficiency as an Important Metric in Drug Design

3. Can the pharmaceutical industry reduce attrition rates?

4. The right compound in the right assay at the right time: an integrated discovery DMPK strategy

5. The Influence of DMPK as an Integrated Partner in Modern Drug Discovery

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