Identification and Characterization of a Blood–Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor-Reference-Cited by-同舟云学术

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Identification and Characterization of a Blood–Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor

Published:2024-08-03 Issue:16 Volume:67 Page:13639-13665
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heitmann Tyler¹,Liao Gangling²,Ernst Glen²,Poslusney Michael²,van Kralingen Thomas²,Li Ye²,Masi Megan¹^ORCID,DePasquale Michael²,Buchler Ingrid²,Wei Huijun¹²,Carr Gregory V.¹²^ORCID,Shlevkov Evgeny²^ORCID,Lu Mengsi³,Jessen Henning³,Barrow James C.¹²^ORCID

Affiliation:

1. Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States

2. Lieber Institute for Brain Development, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States

3. Institute of Organic Chemistry and CIBSS─Centre for Integrative Biological Signaling Studies, Albert-Ludwigs-University, Albertstr. 21, Freiburg 79104, Germany

Funder

Deutsche Forschungsgemeinschaft

Lieber Institute for Brain Development

National Institute of Mental Health

Volkswagen Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00190

Reference61 articles.

1. The inositol pyrophosphate pathway in health and diseases

2. Intracellular signalling: Inositol phosphates – whither bound?

3. Inositol pyrophosphates: structure, enzymology and function

4. Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis

5. GRAB: A Physiologic Guanine Nucleotide Exchange Factor for Rab3a, which Interacts with Inositol Hexakisphosphate Kinase

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