Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome-Reference-Cited by-同舟云学术

Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome

Published:2019-09-27 Issue:20 Volume:62 Page:9246-9253
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhan Wenhu¹,Hsu Hao-Chi²,Morgan Trevor³,Ouellette Tierra¹,Burns-Huang Kristin¹,Hara Ryoma⁴,Wright Adrian G.³,Imaeda Toshihiro⁴,Okamoto Rei⁴,Sato Kenjiro⁴,Michino Mayako⁴,Ramjee Manoj³,Aso Kazuyoshi⁴,Meinke Peter T.⁴,Foley Michael⁴,Nathan Carl F.¹,Li Huilin²^ORCID,Lin Gang¹^ORCID

Affiliation:

1. Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, New York 10065, United States

2. Structural Biology Program, Van Andel Institute, 333 Bostwick Avenue Northeast, Grand Rapids, Michigan 49503, United States

3. Cyclofluidic Limited, Biopark Broadwater Road, Welwyn Garden City AL7 3AX, U.K.

4. Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10065, United States

Funder

Weill Cornell Medical College

National Institute of Allergy and Infectious Diseases

Cornell University

Tri-Institutional Therapeutics Discovery Institute

Weill Cornell Medicine Matching Fund

William Randolph Hearst Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01187

Reference40 articles.

1. World Health Organization Global Tuberculosis Report; World Health Organization, 2018.

2. Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

3. Proteasome inhibitors in cancer therapy

4. Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

5. Structure- and function-based design of Plasmodium-selective proteasome inhibitors

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