Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors

Author:

Zhang Hao1ORCID,Ginn John2,Zhan Wenhu1ORCID,Liu Yi J.1,Leung Annie3,Toita Akinori2,Okamoto Rei2,Wong Tzu-Tshin2,Imaeda Toshihiro2,Hara Ryoma2,Yukawa Takafumi2,Michino Mayako2,Vendome Jeremie4,Beuming Thijs4,Sato Kenjiro2,Aso Kazuyoshi2,Meinke Peter T.2ORCID,Nathan Carl F.1,Kirkman Laura A.13,Lin Gang1ORCID

Affiliation:

1. Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States

2. Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th St, New York, New York 10065, United States

3. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, 1300 York Ave., New York, New York 10065, United States

4. Schrödinger, Inc., New York, New York 10036, United States

Funder

Weill Cornell Medical College

Brockman Foundation

National Institute of Allergy and Infectious Diseases

Cornell University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference43 articles.

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