A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification
Author:
Affiliation:
1. Cellzome, Meyerhofstrasse 1, Heidelberg 69117, Germany
2. GlaxoSmithKline Tres Cantos, 28760 Tres Cantos, Madrid, Spain
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00673
Reference62 articles.
1. Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions
2. The Ecstasy and Agony of Assay Interference Compounds
3. The importance of triaging in determining the quality of output from high-throughput screening
4. Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations
5. Integrating biophysics with HTS-driven drug discovery projects
Cited by 19 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein–Ligand Interactions and High Selectivity;Journal of Medicinal Chemistry;2024-01-10
2. Target-based drug discovery: Applications of fluorescence techniques in high throughput and fragment-based screening;Heliyon;2024-01
3. Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication;Communications Biology;2023-09-28
4. Fragment-based design, synthesis and biological evaluation of theophylline derivatives as ATAD2 inhibitors in BT-549 cells;Journal of Enzyme Inhibition and Medicinal Chemistry;2023-08-03
5. Accounting for Solvation Correlation Effects on the Thermodynamics of Water Networks in Protein Cavities;Journal of Chemical Information and Modeling;2023-03-14
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3