Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics-Reference-Cited by-同舟云学术

Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics

Published:2019-10-31 Issue:5 Volume:63 Page:2527-2546
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Klug Dana M.¹,Tschiegg Laura¹,Diaz Rosario²,Rojas-Barros Domingo²,Perez-Moreno Guiomar²,Ceballos Gloria²,García-Hernández Raquel²,Martinez-Martinez Maria Santos³,Manzano Pilar³,Ruiz Luis Miguel²,Caffrey Conor R.⁴,Gamarro Francisco²,Pacanowska Dolores Gonzalez²,Ferrins Lori¹^ORCID,Navarro Miguel²,Pollastri Michael P.¹^ORCID

Affiliation:

1. Department of Chemistry & Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States

2. Instituto de Parasitología y Biomedicina “López-Neyra”, Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain

3. Diseases of the Developing World (DDW), Tres Cantos Medicines Development Campus, GlaxoSmithKline, Tres Cantos 28760, Spain

4. Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States

Funder

Ministerio de Econom?a y Competitividad

National Institute of Allergy and Infectious Diseases

American Chemical Society

Instituto de Salud Carlos III

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01506

Reference10 articles.

1. World Health Organization. Neglected Tropical Diseases. http://www.who.int/neglected_diseases/diseases/en/ (accessed November 24, 2015).

2. Human African trypanosomiasis

3. aDrugs for Neglected Diseases Initiative. Fexinidazole (HAT). http://www.dndi.org/diseases-projects/portfolio/fexinidazole/ (accessed February 13, 2018).

4. Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial

5. cDrugs for Neglected Diseases Initiative. Acoziborole. http://www.dndi.org/diseases-projects/portfolio/scyx-7158/ (accessed February 13, 2017).

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