Pharmacophore Identification and Structure–Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of <i>Trypanosoma brucei</i>-Reference-Cited by-同舟云学术

Pharmacophore Identification and Structure–Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of Trypanosoma brucei

Published:2024-08-13 Issue:16 Volume:67 Page:13985-14006
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ferrins Lori¹^ORCID,Diaz Rosario²,Cordon-Obras Carlos²,Rojas-Barros Domingo²,Quotadamo Antonio¹³,Oehme Daniel P.¹^ORCID,Ceballos-Pérez Gloria²,Swaminathan Uma¹,Pérez-Moreno Guiomar²,Bosch-Navarrete Cristina²,García-Hernández Raquel²,Gomez-Liñan Claudia²,Saura Andreu²,Ruiz-Perez Luis Miguel²,Gamarro Francisco²,Martinez-Martinez Maria Santos⁴,Manzano Pilar⁴,González-Pacanowska Dolores²^ORCID,Navarro Miguel²,Pollastri Michael P.¹^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States

2. Instituto de Parasitología y Biomedicina “López-Neyra” Consejo Superior de Investigaciones Científicas (CSIC), Granada 18100, Spain

3. Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy

4. Tres Cantos R&D Center, GSK, Tres Cantos 28760, Spain

Funder

Ministerio de Ciencia, Innovación y Universidades

European Regional Development Fund

National Institute of Allergy and Infectious Diseases

Red de Investigación Cooperativa en Enfermedades Tropicales

Instituto de Salud Carlos III

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00785

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