Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells-Reference-Cited by-同舟云学术

Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells

Published:2019-11-14 Issue:23 Volume:62 Page:10867-10896
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Han Shuai¹,Li Xin¹²,Xia Yun¹²,Yu Zhengsen¹,Cai Ningning¹³,Malwal Satish R.⁴^ORCID,Han Xu⁵,Oldfield Eric⁴^ORCID,Zhang Yonghui¹²³^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, 100084 Beijing, China

2. Joint Graduate Program of Peking-Tsinghua-NIBS, School of Life Sciences, Tsinghua University, 100084 Beijing, China

3. Collaborative Innovation Center for Biotherapy, Sichuan University, 610041 Chengdu, Sichuan, China

4. Department of Chemistry, University of Illinois at Urbana—Champaign, Urbana, Illinois 61801, United States

5. Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 300308 Tianjin, China

Funder

Ministry of Education of the People's Republic of China

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Beijing Municipality

U.S. Public Health Service

Beijing Municipal Science and Technology Commission

National Natural Science Foundation of China

Tsinghua Peking Center for Life Science

Beijing Advanced Innovation Centre for Structural Biology

Publisher

American Chemical Society (ACS)

Subject