Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases

Author:

De Schutter Joris W.1,Park Jaeok2,Leung Chun Yuen1,Gormley Patrick3,Lin Yih-Shyan1,Hu Zheping1,Berghuis Albert M.245,Poirier Judes3,Tsantrizos Youla S.125

Affiliation:

1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada

2. Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada

3. Douglas Mental Health University Institute, 6825 Lasalle, Verdun, Quebec, H4H 1R3, Canada

4. Department of Microbiology and Immunology, McGill University, 3775 Rue University, Montreal, Quebec H3A 2B4, Canada

5. Groupe de Recherche Axé sur la Structure des Protéines, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec H3G 0B1, Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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