Structure–Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability-Reference-Cited by-同舟云学术

Structure–Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

Published:2019-10-29 Issue:5 Volume:63 Page:2343-2357
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Slack Rachel D.¹,Ku Therese C.¹^ORCID,Cao Jianjing¹,Giancola JoLynn B.¹,Bonifazi Alessandro¹^ORCID,Loland Claus J.²,Gadiano Alexandra¹³,Lam Jenny¹³,Rais Rana³^ORCID,Slusher Barbara S.³^ORCID,Coggiano Mark¹,Tanda Gianluigi¹,Newman Amy Hauck¹^ORCID

Affiliation:

1. Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse−Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States

2. Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark

3. Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, Maryland 21205, United States

Funder

Det Frie Forskningsr?d

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01188

Reference78 articles.

1. NIDA. Overdose Death Rates. https://www.drugabuse.gov/related-topics/trends-statistics/overdose-death-rates (accessed Apr 10, 2019).

2. DEA. 2017 National Drug Threat Assessment. https://www.dea.gov/documents/2017/10/01/2017-national-drug-threat-assessment (accessed Apr 15, 2019).