Structure–Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability

Author:

Slack Rachel D.1,Ku Therese C.1ORCID,Cao Jianjing1,Giancola JoLynn B.1,Bonifazi Alessandro1ORCID,Loland Claus J.2,Gadiano Alexandra13,Lam Jenny13,Rais Rana3ORCID,Slusher Barbara S.3ORCID,Coggiano Mark1,Tanda Gianluigi1,Newman Amy Hauck1ORCID

Affiliation:

1. Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse−Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States

2. Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark

3. Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, Maryland 21205, United States

Funder

Det Frie Forskningsr?d

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference78 articles.

1. NIDA. Overdose Death Rates. https://www.drugabuse.gov/related-topics/trends-statistics/overdose-death-rates (accessed Apr 10, 2019).

2. DEA. 2017 National Drug Threat Assessment. https://www.dea.gov/documents/2017/10/01/2017-national-drug-threat-assessment (accessed Apr 15, 2019).

3. Evaluation of the “Pipeline” for Development of Medications for Cocaine Use Disorder: A Review of Translational Preclinical, Human Laboratory, and Clinical Trial Research

4. Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence

5. Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3