Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors

Author:

Cho Hanna1,Shin Injae1,Cho Kyungseon2,Yoon Hojong2ORCID,Yoo Eun Kyung3,Kim Mi-Jin3,Park Sungmi3,Lee In-Kyu34,Kim Nam Doo56,Sim Taebo12ORCID

Affiliation:

1. KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea

2. Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), 5 Hwarangro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea

3. Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 41404, Republic of Korea

4. Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Republic of Korea

5. Daegu-Gyeongbuk Medical Innovation Foundation, 2387 Dalgubeol-daero, Suseong-gu, Daegu 42019, Republic of Korea

6. NDBio Therapeutics Inc., 32 Songdogwahak-ro, Yeonsu-gu, Incheon 21984, Republic of Korea

Funder

Korea Health Industry Development Institute

National Research Foundation of Korea

Korea Institute of Science and Technology

KU-KIST Graduate School of Converging Science and Technology Program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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