Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands-Reference-Cited by-同舟云学术

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Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands

Published:2020-03 Issue: Volume:96 Page:103643
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Ghinet Alina,Thuru Xavier,Floquet Emilie,Dubois Joëlle,Farce Amaury,Rigo Benoît

Funder

National Cancer Institute

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference24 articles.

1. https://www.who.int/news-room/fact-sheets/detail/cancer, consulted on May 2019.

2. Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)

3. http://clinicaltrials.gov/, consulted on September 2019.

4. Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

5. Design, Synthesis, and Biological Characterization of Novel Mitochondria Targeted Dichloroacetate-Loaded Compounds with Antileukemic Activity

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1. Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase;Pharmaceuticals;2023-06-16

2. Cytotoxic derivatives of dichloroacetic acid and some metal complexes;Archiv der Pharmazie;2022-08-19

3. Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells;Medicines;2022-06-08

4. Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy;European Journal of Medicinal Chemistry;2021-12

5. Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy;Journal of Medicinal Chemistry;2021-06-08

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