Design, Synthesis, and Biological Characterization of Novel Mitochondria Targeted Dichloroacetate-Loaded Compounds with Antileukemic Activity

Author:

Trapella Claudio1,Voltan Rebecca2,Melloni Elisabetta2,Tisato Veronica2,Celeghini Claudio3,Bianco Sara1,Fantinati Anna1,Salvadori Severo1,Guerrini Remo1,Secchiero Paola2,Zauli Giorgio4

Affiliation:

1. Department of Chemical and Pharmaceutical Sciences and LTTA Centre, University of Ferrara, Via Fossato di Mortara 17, 44121 Ferrara, Italy

2. Department of Morphology, Surgery, Experimental Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy

3. Department of Life Sciences, University of Trieste, 34128 Trieste, Italy

4. Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Via dell’Istria 65/1, 34137 Trieste, Italy

Funder

Associazione Italiana per la Ricerca sul Cancro

Ministero dell'Istruzione, dell'Università e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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