Discovery of N-(4-Aminobutyl)-N′-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1)-Reference-Cited by-同舟云学术

Discovery of N-(4-Aminobutyl)-N′-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1)

Published:2019-12-16 Issue:1 Volume:63 Page:425-432
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lunk Ina¹,Litty Felix-Alexander¹,Hennig Sven²^ORCID,Vetter Ingrid R.³,Kotthaus Jürke¹,Altmann Karin S.¹,Ott Gudrun¹,Havemeyer Antje¹,García Carmen Carrillo¹,Clement Bernd¹^ORCID,Schade Dennis¹³⁴^ORCID

Affiliation:

1. Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University Kiel, Gutenbergstrasse 76, D-24118 Kiel, Germany

2. Department of Chemistry & Pharmaceutical Sciences, VU University Amsterdam, De Boelelaan 1108, The Netherlands

3. Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, D-44227 Dortmund, Germany

4. Partner Site Kiel, DZHK, German Center for Cardiovascular Research, D-24105 Kiel, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01230

Reference31 articles.

1. Modulating the NO generating system from a medicinal chemistry perspective: Current trends and therapeutic options in cardiovascular disease

2. The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis

3. Disruption of methylarginine metabolism impairs vascular homeostasis

4. The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis

5. Developing an Irreversible Inhibitor of Human DDAH-1, an Enzyme Upregulated in Melanoma

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