Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE1 Series EP4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE1 Analog (KMN-159) as a Potent EP4 Agonist-Reference-Cited by-同舟云学术

Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE1 Series EP4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE1 Analog (KMN-159) as a Potent EP4 Agonist

Published:2019-04-09 Issue:9 Volume:62 Page:4731-4741
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Barrett Stephen D.¹^ORCID,Holt Melissa C.¹,Kramer James B.¹,Germain Bradlee¹,Ho Chi S.¹,Ciske Fred L.¹,Kornilov Andrei¹,Colombo Joseph M.¹,Uzieblo Adam¹,O’Malley James P.²,Owen Thomas A.²³,Stein Adam J.¹,Morano Maria I.¹^ORCID

Affiliation:

1. Cayman Chemical Company, Inc., 1180 East Ellsworth Road, Ann Arbor, Michigan 48108, United States

2. Myometrics, LLC, 216 Howard Street, New London, Connecticut 06320, United States

3. Ramapo College of New Jersey, 505 Ramapo Valley Road, Mahwah, New Jersey 07430, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00336

Reference49 articles.

1. Structural features of subtype-selective EP receptor modulators