Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent-Reference-Cited by-同舟云学术

Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent

Published:2020-08-14 Issue:17 Volume:63 Page:9154-9167
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lu Xing¹,Liu Yan-Cheng¹,Orvig Chris²^ORCID,Liang Hong¹,Chen Zhen-Feng¹^ORCID

Affiliation:

1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, P. R. China

2. Department of Chemistry, Faculty of Science, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T1Z1, Canada

Funder

Ministry of Education of the People's Republic of China

Natural Science Foundation of Guangxi Province

National Natural Science Foundation of China

Guangxi Graduate Education

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b02047

Reference48 articles.

1. Cell Death Signaling

2. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

3. Targeting Apoptosis Signaling Pathways for Anticancer Therapy

4. Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy

5. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

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