1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors-Reference-Cited by-同舟云学术

1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors

Published:2020-01-23 Issue:5 Volume:63 Page:2470-2488
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

D’Ascenzio Melissa¹,Secci Daniela¹^ORCID,Carradori Simone²^ORCID,Zara Susi²,Guglielmi Paolo¹,Cirilli Roberto³^ORCID,Pierini Marco¹,Poli Giulio⁴,Tuccinardi Tiziano⁴^ORCID,Angeli Andrea⁵⁶,Supuran Claudiu T.⁵^ORCID

Affiliation:

1. Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy

2. Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy

3. Centro nazionale per il controllo e la valutazione dei farmaci, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy

4. Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy

5. Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy

6. Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica-Voda Alley, 700487 Iasi, Romania

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01434

Reference47 articles.

1. Structure and function of carbonic anhydrases

2. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

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4. Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors

5. Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one

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