Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis-Reference-Cited by-同舟云学术

Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis

Published:2019-11-30 Issue:24 Volume:62 Page:11080-11107
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jiang Fei¹²,Hu Qinghua¹,Zhang Zhimin¹³,Li Hongmei¹²,Li Huili¹,Zhang Dewei¹,Li Hanwen¹,Ma Yu¹,Xu Jingjing⁴,Chen Haifang¹,Cui Yong¹,Zhi Yanle¹^ORCID,Zhang Yanmin¹,Xu Junyu¹^ORCID,Zhu Jiapeng⁴,Lu Tao¹²,Chen Yadong¹²^ORCID

Affiliation:

1. School of Sciences, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, P. R. China

2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P. R. China

3. Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China

4. School of Medicine and Life Sciences, State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China

Funder

China Pharmaceutical University

China Postdoctoral Science Foundation

Priority Academic Program Development of Jiangsu Higher Education Institutions

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01010

Reference58 articles.