Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines-Reference-Cited by-同舟云学术

Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines

Published:2019-07-11 Issue:15 Volume:62 Page:7089-7110
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cerchia Carmen¹,Nasso Rosarita²³,Mori Matteo⁴,Villa Stefania⁴^ORCID,Gelain Arianna⁴,Capasso Alessandra²,Aliotta Federica²,Simonetti Martina²,Rullo Rosario²⁵,Masullo Mariorosario³,De Vendittis Emmanuele²,Ruocco Maria Rosaria²,Lavecchia Antonio¹^ORCID

Affiliation:

1. Department of Pharmacy, “Drug Discovery” Laboratory, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy

2. Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy

3. Department of Movement Sciences and Wellness, University of Naples “Parthenope”, 80133 Naples, Italy

4. Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli, 25, 20133 Milan, Italy

5. Institute for the Animal Production Systems in the Mediterranean Environment, Via Argine 1085, 80147 Naples, Italy

Funder

Regione Campania

Combattere la resistenza tumorale: piattaforma integrata multidisciplinare per un approccio tecnologico innovativo alle oncoterapie - CAMPANIA ONCOTERAPIE

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00632

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4. Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

5. Cdc25: mechanisms of checkpoint inhibition and recovery

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