Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines-Reference-Cited by-同舟云学术

Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines

Published:2019-07-11 Issue:15 Volume:62 Page:7089-7110
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cerchia Carmen¹,Nasso Rosarita²³,Mori Matteo⁴,Villa Stefania⁴^ORCID,Gelain Arianna⁴,Capasso Alessandra²,Aliotta Federica²,Simonetti Martina²,Rullo Rosario²⁵,Masullo Mariorosario³,De Vendittis Emmanuele²,Ruocco Maria Rosaria²,Lavecchia Antonio¹^ORCID

Affiliation:

1. Department of Pharmacy, “Drug Discovery” Laboratory, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy

2. Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy

3. Department of Movement Sciences and Wellness, University of Naples “Parthenope”, 80133 Naples, Italy

4. Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli, 25, 20133 Milan, Italy

5. Institute for the Animal Production Systems in the Mediterranean Environment, Via Argine 1085, 80147 Naples, Italy

Funder

Regione Campania

Combattere la resistenza tumorale: piattaforma integrata multidisciplinare per un approccio tecnologico innovativo alle oncoterapie - CAMPANIA ONCOTERAPIE

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00632

Reference79 articles.

1. cdc25+ functions as an inducer in the mitotic control of fission yeast

2. Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

3. Moderate variations in CDC25B protein levels modulate the response to DNA damaging agents

4. Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

5. Cdc25: mechanisms of checkpoint inhibition and recovery

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeted Integration of siRNA against Porcine Cytomegalovirus (PCMV) Enhances the Resistance of Porcine Cells to PCMV;Microorganisms;2024-04-22

2. Discovery of new inhibitors of Cdc25B phosphatases by molecular docking-based virtual screening;Journal of Molecular Structure;2024-03

3. Druggable targets of protein tyrosine phosphatase Family, viz. PTP1B, SHP2, Cdc25, and LMW-PTP: Current scenario on medicinal Attributes, and SAR insights;Bioorganic Chemistry;2024-03

4. 6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers;European Journal of Medicinal Chemistry;2023-10

5. Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures;Life;2023-04-21