Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors-Reference-Cited by-同舟云学术

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

Published:2019-10-30 Issue:22 Volume:62 Page:10391-10401
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Friggeri Laura¹,Hargrove Tatiana Y.¹,Wawrzak Zdzislaw²,Guengerich F. Peter¹^ORCID,Lepesheva Galina I.¹³⁴^ORCID

Affiliation:

1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

2. Synchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States

3. Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States

4. Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, United States

Funder

U.S. Department of Health and Human Services

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01485

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