Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease-Reference-Cited by-同舟云学术

Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease

Published:2019-06-11 Issue:13 Volume:62 Page:6146-6162
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ma Yuying¹,Li Linfeng²^ORCID,He Shuai¹,Shang Chengyou¹,Sun Yang³,Liu Ning¹,Meek Thomas D.²^ORCID,Wang Yaxin⁴,Shang Luqing¹^ORCID

Affiliation:

1. College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China

2. Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States

3. Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing 100084, China

4. School of Life Sciences, Tianjin University, Tianjin 300110, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Wuhan National Biosafety Laboratory, Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00387

Reference30 articles.

1. Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies

2. Targeted Covalent Inhibitors for Drug Design

3. Structure-based design of targeted covalent inhibitors

4. Covalent inhibitors: an opportunity for rational target selectivity

5. The resurgence of covalent drugs

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