Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors-Reference-Cited by-同舟云学术

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Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors

Published:2019-11-08 Issue:23 Volume:62 Page:10757-10782
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Röhm Sandra¹²^ORCID,Berger Benedict-Tilman¹²,Schröder Martin¹²,Chaikuad Apirat¹²^ORCID,Winkel Rob³,Hekking Koen F. W.³,Benningshof Jorg J. C.³,Müller Gerhard⁴,Tesch Roberta¹²,Kudolo Mark⁵,Forster Michael⁵,Laufer Stefan⁵^ORCID,Knapp Stefan¹²^ORCID

Affiliation:

1. Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany

2. Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 15, D-60438 Frankfurt am Main, Germany

3. Mercachem BV, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands

4. Gotham Therapeutics, 430 East 29th Street, Alexandria Center, New York, New York 10016, United States

5. Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

Funder

Novartis

Merck

Merck KGaA

Bayer

Deutschen Konsortium f??r Translationale Krebsforschung

Pfizer

Innovative Medicines Initiative

Ontario Genomics Institute

AbbVie

Wellcome Trust

Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo

Boehringer Ingelheim

Johnson and Johnson

University of North Carolina

Canada Foundation for Innovation

Takeda Pharmaceutical Company

Deutsche Forschungsgemeinschaft

Ontario Ministry of Research, Innovation and Science

SFB autophagy

SGC

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01227

Reference46 articles.

1. Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

2. Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

3. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

4. Pamapimod, a Novel p38 Mitogen-Activated Protein Kinase Inhibitor: Preclinical Analysis of Efficacy and Selectivity

5. Pathway to the Clinic: Inhibition of P38 MAP Kinase. A Review of Ten Chemotypes Selected for Development

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