Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity-Reference-Cited by-同舟云学术

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Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity

Published:2020-01-02 Issue:3 Volume:63 Page:1178-1198
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sibley Christopher D.¹,Morris Emily A.¹,Kharel Yugesh²,Brown Anne M.³⁴,Huang Tao²,Bevan David R.³⁴,Lynch Kevin R.²^ORCID,Santos Webster L.¹⁴^ORCID

Affiliation:

1. Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States

2. Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, United States

3. Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, United States

4. Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, United States

Funder

Commonwealth of Virginia

Center for Scientific Review

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01508

Reference40 articles.

1. Sphingosine 1-phosphate and cancer

2. Sphingosine kinase 1 in breast cancer

3. Mechanisms of sphingosine 1-phosphate receptor signalling in cancer

4. Different Roles of Sphingosine Kinase 1 and 2 in Pancreatic Cancer Progression

5. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

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1. Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury;American Journal of Physiology-Renal Physiology;2022-09-01

2. Room-Temperature, Transition-Metal-Free Arylation of Alcohols with Aryl Bromides;Synthesis;2022-08-29

3. Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney;Science Translational Medicine;2022-08-17

4. Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues;ACS Bio & Med Chem Au;2022-06-29

5. A Novel Sphingosine Kinase Inhibitor Suppresses Chikungunya Virus Infection;Viruses;2022-05-24

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