Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury-Reference-Cited by-同舟云学术

Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury

Published:2022-09-01 Issue:3 Volume:323 Page:F322-F334
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Xie Dengpiao¹²,Hu Gaizun¹,Chen Chaoling¹,Ahmadinejad Fereshteh¹,Wang Weili¹,Li Pin-Lan¹^ORCID,Gewirtz David A.¹,Li Ningjun¹^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia

2. Department of Nephrology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China

Abstract

The present study provides new findings that sphingosine kinase 2 (SphK2) is highly expressed in renal tubules, cisplatin treatment increases the expression of SphK2 in proximal tubular cells and kidneys, and inhibition of SphK2 alleviates cisplatin-induced kidney injury by suppressing the activation of NF-κB, production of inflammatory factors, and apoptosis. SphK2 may serve as a potential therapeutic target for the prevention or treatment of cisplatin-induced nephrotoxicity.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00229.2021

Reference80 articles.

1. Omeprazole protects against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and transporter-mediated cisplatin accumulation in rats and HK-2 cells