Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis-Reference-Cited by-同舟云学术

Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis

Published:2019-12-17 Issue:2 Volume:63 Page:756-783
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tear Westley F.¹,Bag Seema¹,Diaz-Gonzalez Rosario²,Ceballos-Pérez Gloria²,Rojas-Barros Domingo I.²,Cordon-Obras Carlos²,Pérez-Moreno Guiomar²,García-Hernández Raquel²,Martinez-Martinez Maria Santos³,Ruiz-Perez Luis Miguel²,Gamarro Francisco²,Gonzalez Pacanowska Dolores²,Caffrey Conor R.⁴,Ferrins Lori¹^ORCID,Manzano Pilar³,Navarro Miguel²,Pollastri Michael P.¹^ORCID

Affiliation:

1. Department of Chemistry & Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States

2. Instituto de Parasitología y Biomedicina “López-Neyra”, Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain

3. Tres Cantos Medicines Development Campus, DDW and CIB, GlaxoSmithKline, Tres Cantos 28760, Spain

4. Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States

Funder

Ministerio de Econom?a, Industria y Competitividad, Gobierno de Espa?a

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01741

Reference43 articles.

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