Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design-Reference-Cited by-同舟云学术

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design

Published:2019-07-12 Issue:15 Volume:62 Page:7264-7288
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dong Xiaowu^ORCID,Zhan Wenhu,Zhao Mengting,Che Jinxin,Dai Xiaoyang,Wu Yizhe,Xu Lei¹,Zhou Yubo¹,Zhao Yanmei,Tian Tian,Cheng Gang²,Jin Zegao,Li Jia¹,Shao Yanfei³,He Qiaojun,Yang Bo,Weng Qinjie,Hu Yongzhou^ORCID

Affiliation:

1. National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

2. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China

3. Department of Pharmacy, Zhejiang Provincial People’s Hospital, Hangzhou 310014, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Health Bureau of Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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