Discovery of novel Akt1 inhibitors by an ensemble-based virtual screening method, molecular dynamics simulation, and in vitro biological activity testing-Reference-Cited by-同舟云学术

Discovery of novel Akt1 inhibitors by an ensemble-based virtual screening method, molecular dynamics simulation, and in vitro biological activity testing

Published:2024-01-19 Issue: Volume: Page:
ISSN:1381-1991
Container-title:Molecular Diversity
language:en
Short-container-title:Mol Divers

Author:

Zhang Wen,Hu Mei-Ling,Shi Xiu-Yun,Chen Xiang-Long,Su Xue,Qi Hua-Zhao,Yuan Li,Zhang Hui

Funder

Science and Technology Program Project of Gansu Province

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s11030-023-10788-3.pdf

Reference50 articles.

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3. Xing Y, Lin NU, Maurer M, Huiqin C, Armeen M (2019) Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation. Breast Cancer Res 21:1–12. https://doi.org/10.1186/s13058-019-1154-8

4. Yang ZZ, Tschopp O, Hemmings-Mieszczak M (2003) Protein kinase Bα/Akt1 regulates placental development and fetal growth. J Biol Chem 278(34):32124–32131

5. Rao G, Pierobon M, Kim IK (2017) Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations. Sci Rep 7(1):1–12. https://doi.org/10.1038/s41598-017-06128-9

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