Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent-Reference-Cited by-同舟云学术

Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent

Published:2019-05-17 Issue:11 Volume:62 Page:5579-5593
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Xianglei¹²,Dong Guangyu²³,Li Heng¹²,Chen Wuyan¹,Li Jian¹,Feng Chunlan¹,Gu Zhanni¹,Zhu Fenghua¹,Zhang Rui¹²,Li Minjun⁴,Tang Wei¹²,Liu Hong¹²^ORCID,Xu Yechun¹²^ORCID

Affiliation:

1. CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Drug Discovery and Design Center, Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

3. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

4. Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China

Funder

Ministry of Science and Technology of the People's Republic of China

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine