Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease

Author:

Zhou Jianhui12,Wang Ning3,Wang Mengxue124,Hu Yuting124,Zhang Zhenwei245,Gu Zhiyong465,Wang Jing124,Shou Haowen24,Cheng Xi465ORCID,Liu Hong12465ORCID,Li Yang3,Zhou Yu1245ORCID

Affiliation:

1. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China

2. Drug Discovery & Development Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. Department of Pharmacology, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Science, Fudan University, Shanghai 200032, China

4. University of Chinese Academy of Sciences, Beijing 100049, China

5. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China

6. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Funder

Ministry of Science and Technology of the People's Republic of China

State Key Laboratory of Drug Research, Chinese Academy of Sciences

Shanghai Municipal Education Commission

Innovative Research Team of High-level Local University in Shanghai

National Natural Science Foundation of China

Science and Technology Innovation Plan Of Shanghai Science and Technology Commission

Program of Shanghai Academic Research Leader

Publisher

American Chemical Society (ACS)

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