Novel Pyrazolo[4,3-d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model-Reference-Cited by-同舟云学术

Novel Pyrazolo[4,3-d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model

Published:2019-03-29 Issue:8 Volume:62 Page:4013-4031
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shi Jing Bo¹,Chen Liu Zeng¹,Wang Bao Shi¹,Huang Xin¹,Jiao Ming Ming¹,Liu Ming Ming¹,Tang Wen Jian¹^ORCID,Liu Xin Hua¹^ORCID

Affiliation:

1. School of Pharmacy, Anhui Medical University, Hefei 230032, P. R. China

Funder

Natural Science Foundation of Anhui Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00039

Reference38 articles.

1. Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dimerization Inhibitors that are Orally Active in Rodent Pain Models

2. Synthesis and Biological Evaluation of Novel 5-Benzylidenethiazolidine-2,4-dione Derivatives for the Treatment of Inflammatory Diseases

3. Nitric oxide synthase and structure-based inhibitor design

4. Inducible nitric oxide synthase: Good or bad?

5. Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advancements in the Research of New Modulators of Nitric Oxide Synthases Activity;International Journal of Molecular Sciences;2024-08-03

2. Design and synthesis of forsythin derivatives as anti-inflammatory agents for acute lung injury;European Journal of Medicinal Chemistry;2024-03

3. Design, synthesis, in vitro and in vivo biological evaluation of pterostilbene derivatives for anti-inflammation therapy;Journal of Enzyme Inhibition and Medicinal Chemistry;2024-02-29

4. Mitochondrial-Targeted Ratiometric Near-Infrared Fluorescence Probe for Monitoring Nitric Oxide in Rheumatoid Arthritis;Journal of Medicinal Chemistry;2024-02-15

5. Synthesis, Characterization, and in vitro Anti-Inflammatory Activity of Novel Ferrocenyl(Piperazine-1-Yl)Methanone-based Derivatives;Medicinal Chemistry;2023-11